Alzheimer Inhibitor developed by Jawaharlal Nehru Centre of Advanced Scientific Research

The scientists of Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) operating under Department of Science and Technology has invented a natural product for Alzheimer disease.

Significance

• Alzheimer’s is a disorder that accounts for more than 70% of all types of dementia. 
• It is difficult to develop effective medication for the disease as the disease attributes to multifaceted toxicity.
• The Berberine used in traditional medicines has been converted into Ber-D. Ber-D is antioxidant and soluble. 
• On the other hand, Berberine is toxic to cells and poorly soluble.
• The natural product called Isoquinoline is also used. 
• Isoquinoline is found in India and China and has been used in traditional medicines.

Ber-D

• The Ber-D invented prevents generation of Reactive Oxygen Species. 
• It rescues biomacromolecules from oxidative damages.
• It prevents the accumulation of metal-dependent and independent Amyloid Beta. 
• Amyloid Beta are the peptides of amino acids that build up around the brain cells.

Cause of Alzheimer

• The disease is caused due to abnormal build up of protein around the brain cells. 
• Proteins are made up of amino acids. 
• Therefore, the drug invented prevents deposition of these proteins called Amyloid Beta around the brain cells.
• The medicine invented also helps to prevent DNA damages.